Thermo Fisher Scientific CCR4 Monoclonal Antibody (KH-4F5-D3)
CCR4 단백질을 인식하는 mouse IgG2a 단일클론 항체로, ICC/IF, Flow Cytometry, ELISA 등에 사용 가능. 인간 CCR4 합성 펩타이드 면역원 기반으로 제작되었으며 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1 µg/1×10⁶ cells |
| Flow Cytometry (Flow) | 1.2 µg/1×10⁶ cells |
| ELISA | 1:200–1:400 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KH-4F5-D3 |
| Immunogen | Synthetic peptide corresponding to human CCR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2275705 |
Product Specific Information
This antibody recognizes native human CCR4 protein expressed in transfected mammalian cells.
Target Information
CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells. Unlike other chemokine receptors, CCR4 and CCR8 expression on Th2 cells is transiently increased following TCR and CD28 engagement. Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.
Chemokines are small (approximately 8–14 kD), mostly basic, structurally related molecules that regulate leukocyte trafficking via interactions with 7-transmembrane, G protein-coupled receptors. They play key roles in immune system development, homeostasis, and function, and affect CNS cells and endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into two major subfamilies:
- CXC chemokines: Two cysteines separated by a single amino acid
- CC chemokines: Two cysteines adjacent
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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