Thermo Fisher Scientific ROS1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ROS1 protein. Validated for ICC/IF applications with high specificity. Supplied as liquid, unconjugated form (0.2 mg/mL) in PBS with 40% glycerol. Ideal for research use in signal transduction and kinase pathw...
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- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ROS (Recombinant protein control fragment: Product # RP-107878) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662482 |
Product Specific Information
Immunogen sequence:
DVICLNSDDIM PVALMETKNR EGLNYMVLAT ECGQGEEKSE GPLGSQESES CGLRKEEKEP HADKDFCQEK QVAYCPSGKP EGLNYACLTH SGYGDGSD
Highest antigen sequence identity to the following orthologs:
- Mouse: 68%
- Rat: 66%
Target Information
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases transfer a phosphate group from ATP to substrate proteins, mediating most eukaryotic signal transduction pathways. They regulate metabolism, transcription, cell cycle, cytoskeletal organization, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products, classified into 8 major groups based on their catalytic domain sequences (PTK or STK). The tyrosine kinase group primarily regulates cell-cell interactions such as differentiation, adhesion, motility, and death. Approximately 90 tyrosine kinase genes have been sequenced, including receptor types (e.g., EGFR, FGFR, PDGFR) and cytosolic types (e.g., ABL, JAK, SRC).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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