Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI2D4), TrueMAB
RYBP 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 적합. Human 시료 반응성, carrier-free 형태로 제공되어 다양한 결합 실험에 활용 가능. 고순도 친화 크로마토그래피 정제 제품으로 안정적 성능을 제공.
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Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI2D4), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D4 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of ~1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RYBP is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, which maintains transcriptional repression of genes such as Hox during development.
This complex mediates monoubiquitination of histone H2A at Lys-119, altering chromatin expressibility.
RYBP is involved in X chromosome silencing, TP53 regulation, and apoptosis control via ubiquitin-mediated proteasomal degradation of target proteins (e.g., FANK1).
It may also function as a transcriptional repressor and contribute to tumor growth suppression in breast cancer by down-regulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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