Thermo Fisher Scientific PTPN22 Polyclonal Antibody
PTPN22 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 고순도 친화 크로마토그래피 정제. PBS/glycerol buffer에 보관하며 연구용으로 사용됩니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: [참고 문헌 없음]
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PTPN22 (Accession Q9Y2R2), amino acids K770–I807 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818152 |
Product Specific Information
This antibody detects endogenous levels of total PTPN22.
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
A missense SNP in PTPN22 encodes a hematopoietic-specific phosphatase (Lyp). The risk allele, found in about 17% of Caucasian individuals and 28% of those with rheumatoid arthritis, is thought to disrupt the P1 proline-rich motif crucial for interaction with the SH3 domain of CSK. This alteration may affect normal T cell regulatory functions.
The CSK–PTPN22 interaction is highly specific, suggesting that PTPN22 may act as an effector or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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