Thermo Fisher Scientific TNFSF14 Polyclonal Antibody
TNFSF14 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human TNFSF14 (amino acids 141–240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. It is induced by cytokines such as TNF and Fas ligand through their death domain-containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family.
A novel DD-containing molecule, Daxx (death associated protein 6), has been cloned from mouse, human, and monkey. Daxx binds specifically to the Fas death domain, enhances Fas-induced apoptosis, and activates the Jun N-terminal kinase (JNK) pathway. It is widely expressed in fetal and adult tissues, indicating its important role in Fas signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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