Thermo Fisher Scientific PERP Polyclonal Antibody
PERP 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. p53 유도 세포사멸 연구용으로 유용합니다.
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Thermo Fisher Scientific PERP Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PERP (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902075 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP, and PERP, have been identified and cloned recently.
PERP (also termed PIGPC1 and THW) is a plasma membrane protein.
p53 binds to the promoter of PERP and transcriptionally activates the PERP gene; the translated PERP protein mediates p53-induced apoptosis.
The expression of PERP causes cell death and acts as a mediator of p53-induced apoptosis.
PERP shares sequence similarity with PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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