Thermo Fisher Scientific RAP80 Polyclonal Antibody
RAP80 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. BRCA1 복합체의 DNA 손상 반응 연구에 적합하며, 고순도 액상 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- PA5142496
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TRRQKEAKTKSDSG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933143 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
RAP80 was initially identified as a zinc-finger containing nuclear protein highly expressed in testis and interacting with the retinoid-related testis-associated receptor (RTR). It is recruited by the Coiled-coil domain 98 (CCDC98) protein to BRCA1, enabling BRCA1 foci formation in response to DNA damage from ionizing radiation. RAP80 and CCDC98 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 show increased sensitivity to ionizing radiation, though less than BRCA1-depleted cells, indicating their partial role in BRCA1-mediated DNA damage response. At least four isoforms of RAP80 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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