Thermo Fisher Scientific SEPT5 Polyclonal Antibody
SEPT5 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. PBS, 50% glycerol, 0.02% sodium azide 포함. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SEPT5 (Accession Q99719), corresponding to amino acid residues R207–G257 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853450 |
Product Specific Information
Antibody detects endogenous levels of total SEPT5.
Target Information
The SEPT5 gene belongs to the septin family of nucleotide-binding proteins, first described in yeast as cell division cycle regulatory proteins. Septins are conserved across species and play a role in cytoskeletal organization. Disruption of septin function affects cytokinesis, leading to multinucleate or polyploid cells.
This gene is located on chromosome 22q11, a region often deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and SEPT5 has been observed in acute myeloid leukemia cases.
Two transcript variants (2.2 kb and 3.5 kb) have been identified, differing in polyadenylation signal usage. An alternatively spliced transcript with a distinct 5′ end has also been reported, though its full-length sequence remains undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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