Thermo Fisher Scientific DCC Polyclonal Antibody, Biotin
DCC 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, IP 등 다양한 응용에 적합합니다. 사람, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1330–1380 on rat DCC protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein belongs to the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones toward sources of netrin 1 ligand. The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand. It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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