Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI2C1), TrueMAB
MDM4 단백질을 인식하는 마우스 단클론 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간 시료 반응성, TrueMAB 형식. 고순도(affinity chromatography)로 정제된 1 mg/mL 액상 제품. 연구용으로 p53 관련 단백질 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C1 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also designated MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene encoding MDMX is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus, increasing p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. MDMX also binds p73 and stabilizes its level, increasing the half-life of p73 by binding to MDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항체 관련 항원 구조 이미지: TA505750_MDMX_O15151-1_House_mouse.svg 및 TA505750_MDMX_O15151-1_House_mouse_PDP.jpeg)
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