Thermo Fisher Scientific Nebulin Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Nebulin. Recombinant protein control fragment (Product #RP-102106). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Nebulin,uniProtId:P20929-1,ncbiNodeId:9606,antigenRange:5992-6123,antigenLength:6669,antigenImageFileName:PA5-53457_Nebulin_P20929-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53457_Nebulin_P20929-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644585

Product Specific Information

Immunogen sequence: DTPDMLRAKN ATQILNEKEY KRDLELEVKG RGLNAMANET PDFMRARNAT DIASQIKYKQ SAEMEKANFT SVVDTPEIIH AQQVKNLSSQ KKYKEDAEKS MSYYETVLDT PEIQRVRENQ KNFSLLQYQC DL

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.

Target Information

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kDa due to alternative splicing that is tissue-, species-, and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Mutations in this gene are associated with recessive nemaline myopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.