Thermo Fisher Scientific Ephrin A5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Ephrin A5 for Western blot applications. Recognizes N-terminal peptide (aa 66–115) with broad species homology. Supplied as unconjugated liquid form, affinity purified, stored at -20°C in PBS with sucrose and ...
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Applications
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human EFNA5 (aa 66–115) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608566 |
Product Specific Information
- Peptide sequence: EDSVPEDKTE RYVLYMVNFD GYSACDHTSK GFKRWECNRP HSPNGPLKFS
- Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 86%
Target Information
Ephrin A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases crucial for migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. It binds promiscuously to Eph receptors on adjacent cells, leading to contact-dependent bidirectional signaling.
Forward signaling occurs downstream of the receptor, while reverse signaling occurs downstream of the ephrin ligand. Ephrin A5 induces compartmentalized signaling within caveolae-like membrane microdomains, requiring Fyn tyrosine kinase activity.
It activates EPHA3 to regulate cell-cell adhesion and cytoskeletal organization, and with EPHA2 may regulate lens fiber cell shape and transparency. Ephrin A5 also mediates axon fasciculation and communication between pancreatic islet cells, influencing glucose-stimulated insulin secretion. It is a cognate/functional ligand for EPHA7, involved in brain development and modulation of cell-cell adhesion and repulsion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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