Thermo Fisher Scientific Phospho-PRAS40 (Ser183) Polyclonal Antibody
PRAS40의 Ser183 인산화 상태를 검출하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간 및 마우스 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA578600
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PRAS40 (phospho Ser183). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736415 |
Product Specific Information
- Positive Control: 293T, 293T (100 nM Rapamycin, 30 min), 293T (100 nM Insulin, 30 min), 293T (100 nM Rapamycin + 100 nM Insulin, 30 min)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis after various cell death signals.
AKT1S1 (PRAS40) is a proline-rich substrate of kinase AKT1 and plays a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia.
It is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), which controls cell growth and cycle, and acts as a negative regulator of autophagy.
Treatment with insulin-like growth factor-1 (IGF1) can induce phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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