Thermo Fisher Scientific Importin 7 Polyclonal Antibody
Importin 7 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 검증 완료. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제. 0.1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IPO7. Recombinant protein control fragment (Product # RP-91864) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789810 |
Product Specific Information
Immunogen sequence:
RAYACHAEHE NDSDDDDEAE DDDETEELGS DEDDIDEDGQ EYLEILAKQA GEDGDDEDWE EDDAEETALE GYSTIIDDED NPVDEY
Target Information
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran’s GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP. It also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and can cross the nuclear envelope rapidly in both directions. At least four importin beta-like transport receptors — importin beta, transportin, RanBP5, and RanBP7 — directly bind and import ribosomal proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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