Thermo Fisher Scientific XPA Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat XPA protein. Validated for IHC and IHC-P applications. High purity (>95%) and antigen affinity purified. Supplied as liquid in PBS with glycerol, for research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 215–260 of Human XPA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803053 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The XPA (xeroderma pigmentosum group A) protein specifically recognizes UV- or chemically damaged DNA lesions and triggers the nucleotide excision repair process. XPA binds to replication protein A (RPA) or excision repair cross complementing 1 protein (ERCC1). In the absence of nucleotide excision repair, unrepaired DNA lesions may lead to accumulation of mutations and cancer. Xeroderma pigmentosum patients have a >2000-fold increased risk of developing skin cancer in sun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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