Thermo Fisher Scientific VEGFB Polyclonal Antibody
VEGFB 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%) 제품으로 연구용에 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–150 of Human VEGFB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803051 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors sharing a conserved pattern of eight cysteine residues and common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis.
VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB167 and VEGFB186.
- VEGFB167: Highly basic heparin-binding protein, remains with the cell or extracellular matrix.
- VEGFB186: Readily secreted form.
VEGFB stimulates endothelial cell proliferation and binds to the tyrosine kinase receptor VEGFR1 (flt1), but not to VEGFR2. It is widely expressed, especially in heart, skeletal muscle, and pancreas. VEGFB expression in human primary breast cancers has been associated with lymph node metastasis. The VEGFB gene is mapped to chromosome 11q13.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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