Thermo Fisher Scientific ARHGAP22 Polyclonal Antibody
Human ARHGAP22 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 세포 내 Rac1 GTPase 활성 조절 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP22. Recombinant protein control fragment (Product #RP-102890) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638141 |
Product Specific Information
- Immunogen sequence:
PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ GLVTELRAEL CRQRTEYERS VKRIEEGSAD LR - Highest antigen sequence identity:
Mouse – 65%, Rat – 61%
Target Information
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form.
ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm and contains one Rho-GAP domain and one PH domain.
ARHGAP22 functions as a GTPase-activating protein for Rac1, converting it to an inactive GDP-bound state. Through its interaction with ZNF161 (VEZF1), it is thought to play a role in transcription regulation.
Multiple isoforms of ARHGAP22 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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