Thermo Fisher Scientific APBA1 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
ALPNHLHFHSL EHEEAMNAAY SGYVYTHRLF HRGEDEPYSE PYADYGGLQE HVYEEIGDAP ELDARDGLRL YEQERDE

• Highest antigen sequence identity to the following orthologs: mouse 95%, rat 95%.

Target Information

The munc-18 interacting protein (Mint) family consists of conserved adaptor proteins involved in membrane transport and organization.
Mammals have three isoforms: Mint1, Mint2, and Mint3.

• Mint1 and Mint2: Expressed mainly in the brain; interact with Munc18, a key component of synaptic vesicle fusion.
• Mint3: Expressed ubiquitously, lowest in brain and testis; interacts with APP (amyloid precursor protein) via PTB and PDZ domains.
  Mint3 may link APP to transport machinery, influencing its endocytosis and metabolism.
  Abnormal APP metabolism is associated with early-onset Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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