Thermo Fisher Scientific Phospho-FANCD2 (Ser717) Polyclonal Antibody
FANCD2 단백질의 Ser717 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. 고순도 액상 형태로 제공되며, PBS/glycerol buffer에 보존. 인간 및 생쥐 시료 반응성.
- 카탈로그번호
- PA5106174
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: 참고 문헌 보기
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: 참고 문헌 보기
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FANCD2 (Accession Q9BXW9), corresponding to amino acid residues around phosphorylated Ser717 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817572 |
Product Specific Information
Antibody detects endogenous levels of FANCD2 only when phosphorylated at Ser717.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, a disorder affecting all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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