Thermo Fisher Scientific KPNA2 Monoclonal Antibody (C10)
Human KPNA2 단백질을 표적하는 Mouse 모노클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. Recombinant Karyopherin Alpha 2(aa 157-412)를 면역원으로 제작. 단백질 A/G로 정제된 액상 형태, PBS+50% glycerol에 보존. 연구용으로만 사용.
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Thermo Fisher Scientific KPNA2 Monoclonal Antibody (C10)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–30 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–30 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C10 |
| Immunogen | Recombinant protein Karyopherin Alpha 2 (amino acids 157–412 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899105 |
Target Information
The import of proteins into the nucleus involves two steps:
- Energy-independent docking of the protein to the nuclear envelope.
- Energy-dependent translocation through the nuclear pore complex.
Imported proteins require a nuclear localization sequence (NLS), generally composed of short regions of basic amino acids. Proteins involved in the first step include importin and its yeast homolog SRP1, which bind to the NLS.
KPNA2 interacts with NLSs of DNA helicase Q1 and SV40 T antigen, potentially participating in nuclear protein transport and VJ recombination.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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