Thermo Fisher Scientific TRPM5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

This gene encodes a member of the transient receptor potential protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction and has characteristics of a calcium-activated, non-selective cation channel that carries Na⁺, K⁺, and Cs⁺ ions equally well, but not Ca²⁺ ions. It is activated by lower concentrations of intracellular calcium and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat-activated channel showing a steep increase of inward currents at temperatures between 15°C and 35°C. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5 and has been shown to be imprinted, with exclusive expression from the paternal allele.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.