Thermo Fisher Scientific DLAT Recombinant Rabbit Monoclonal Antibody (23GB1010)
DLAT 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow cytometry에 사용 가능. 높은 특이성과 재현성을 제공하며, HEK293F 발현 시스템 기반으로 정제된 액상 형태.
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- MA55398x (2개 옵션)
- 판매단위
- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DLAT Recombinant Rabbit Monoclonal Antibody (23GB1010)
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1010 |
| Immunogen | Synthetic peptide of human Pyruvate Dehydrogenase E2 (594–608AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).
PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A.
The protein product, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by oxidative decarboxylation of pyruvate and transfers them to coenzyme A.
Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with primary biliary cirrhosis (PBC).
In PBC, activated T lymphocytes attack epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed, eventually leading to cirrhosis and liver failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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