Thermo Fisher Scientific Calsequestrin 2 Polyclonal Antibody
Calsequestrin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 반응성, IHC(P) 검증, 항원 친화 크로마토그래피 정제. Ca2+ 결합 단백질 연구용으로 적합하며 심근 관련 단백질 분석에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Calsequestrin 2. Recombinant protein control fragment (Product #RP-101742) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639251 |
Product Specific Information
- Immunogen sequence: LEHKAIGFVM VDAKKEAKLA KKLGFDEEGS LY
- Highest antigen sequence identity to orthologs: Mouse – 84%, Rat – 84%
Target Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein primarily found in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form (CASQ2) is encoded by a separate gene. CASQ2 mainly buffers sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also known as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), which can lead to cardiac arrest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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