Thermo Fisher Scientific alpha Internexin Polyclonal Antibody
신경세포 발달 초기에 발현되는 alpha-Internexin을 인식하는 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. IHC, ICC, ELISA 등 다양한 응용 가능. 단백질 A로 정제된 고순도 항체로 신경세포 연구용 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human alpha Internexin (amino acids 251–350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the neurofilament triplet proteins NF-L, NF-M, and NF-H, sharing similar sequence motifs and intron organization.
Many mature neurons contain alpha-Internexin in addition to NF-L, NF-M, and NF-H, while in some neurons it is the only neurofilament subunit expressed. Antibodies to Internexin serve as unique probes for studying and classifying neuronal types and tracing their processes in tissue sections and cultures.
Due to its early developmental expression, alpha-Internexin is a convenient diagnostic marker for neuronal progenitor cells and cells committed to the neuronal lineage. Although its use in brain tumor studies has not yet been examined, it may hold potential interest in that field.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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