Thermo Fisher Scientific CD137 Polyclonal Antibody
CD137(4-1BB/TNFRSF9)에 특이적인 Thermo Fisher Scientific의 goat polyclonal antibody. Human 시료에 반응하며 WB, ICC/IF, Flow Cytometry, ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태, 0.2 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg for 10^6 cells |
| ELISA | 0.2–0.8 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human 4-1BB/TNFRSF9/CD137 (Leu24–Gln186) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2207743 |
Product Specific Information
Predicted molecular weight for PA1-27993 is 28 kDa.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling maintains the survival of activated and CD8+ memory T cells, promotes clonal expansion, and can suppress myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release regulating peripheral monocyte survival. Soluble CD137 may act as a negative regulator for certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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