Thermo Fisher Scientific TSC1 Monoclonal Antibody (5C8A12)
TSC1 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot, IHC, ICC, ELISA, IP 등 다양한 응용 가능. Recombinant human Hamartin을 면역원으로 사용. Protein A 정제, PBS buffer에 0.1% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 12 publications |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | View 4 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C8A12 |
| Immunogen | Recombinant human Hamartin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533292 |
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases signaling of the mammalian Target of Rapamycin (TOR), a conserved serine/threonine kinase regulating cell growth and cycle through nutrient and growth factor signals. TOR activity is stimulated by Rheb, a Ras superfamily G-protein, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that TSC1/TSC2 decreases Rheb-mediated TOR activation. Overexpression of TSC1 and TSC2 results in decreased GTP/GDP ratio bound to Rheb and inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been identified, but its function remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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