Thermo Fisher Scientific TOP2B Polyclonal Antibody
Human TOP2B 인식 Rabbit Polyclonal Antibody로 Western blot에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. PBS/glycerol 버퍼에 보존되어 안정적이며 연구용으로 DNA 토포이소머라제 II 베타 단백질 검출에 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human TOP2B. Recombinant protein control fragment (Product #RP-104901) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856725 |
Product Specific Information
Immunogen sequence:
DKVPSKTVAA KKGKPSSDTV PKPKRAPKQK KVVEAVNSDS DSEFGIPKKT TTPKGKGRGA KKRKASGSEN EGDYNPGRKT SKTTSKKPKK TSFDQDSDVD IFPSDFPTEP PSLPRTGRAR KEVKYFAESD EEEDDVDF
Target Information
TOP2B (DNA Topoisomerase II Beta) is a protein-coding gene encoding a nuclear enzyme that controls DNA topology during transcription and replication. It facilitates chromosome condensation, chromatid separation, and relieves torsional stress by transiently breaking and rejoining DNA strands.
Two isoforms exist due to gene duplication: beta (chromosome 3) and alpha (chromosome 17). TOP2B is a target of several anticancer agents, and mutations may contribute to drug resistance. Reduced enzyme activity may be linked to ataxia-telangiectasia. Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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