Thermo Fisher Scientific Myofibroblast Marker Monoclonal Antibody (PR 2D3)

Applications and Tested Dilution

Product Specifications

Target Information

Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis, inflammation, repair, wound contraction, and fibrosis. Like smooth muscle cells, myofibroblasts contain microfilament bundles and express α-SM Actin, which is abundant in vascular smooth muscle cells.
These cells secrete inflammatory and anti-inflammatory cytokines, chemokines, growth factors, and extracellular matrix proteins in most organs and tissues. They are present transiently after tissue injury and in fibrocontractive diseases, as well as under normal conditions in tissues such as skin, pulmonary septa, and periodontal ligaments.
Stem cell factor and platelet-derived growth factor (PDGF) are key proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath, smooth muscle cells, and myofibroblasts. This antibody is considered the gold standard for identifying myofibroblasts.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.