
Thermo Fisher Scientific Myofibroblast Marker Monoclonal Antibody (PR 2D3)
Myofibroblast 특이적 단클론 항체(PR 2D3)로, 인간 시료에서 myofibroblast 식별에 사용됩니다. Western blot 및 면역조직화학(IHC) 분석에 적합하며, 200 µg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PR 2D3 |
| Immunogen | Crude homogenate of normal human colorectal mucosa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis, inflammation, repair, wound contraction, and fibrosis. Like smooth muscle cells, myofibroblasts contain microfilament bundles and express α-SM Actin, which is abundant in vascular smooth muscle cells.
These cells secrete inflammatory and anti-inflammatory cytokines, chemokines, growth factors, and extracellular matrix proteins in most organs and tissues. They are present transiently after tissue injury and in fibrocontractive diseases, as well as under normal conditions in tissues such as skin, pulmonary septa, and periodontal ligaments.
Stem cell factor and platelet-derived growth factor (PDGF) are key proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath, smooth muscle cells, and myofibroblasts. This antibody is considered the gold standard for identifying myofibroblasts.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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