Thermo Fisher Scientific CHD8 Polyclonal Antibody
CHD8 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP에 사용 가능. 인간 CHD8의 2252–2302 잔기 영역을 면역원으로 제작. 액상 형태, 4°C 보관, 권장 유효기간 1년. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2252 and 2302 of human chromodomain helicase DNA binding protein 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
CHD8 is a DNA helicase that functions as a chromatin remodeling factor and transcription regulator. It acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. CHD8 suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation. It negatively regulates the Wnt signaling pathway by modulating beta-catenin (CTNNB1) activity and repressing CTNNB1-targeted gene expression. Additionally, CHD8 interacts with CTCF for enhancer blocking and epigenetic remodeling and suppresses STAT3 activity while activating transcription through interaction with ZNF143 in U6 RNA polymerase III transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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