Thermo Fisher Scientific BMP-2 Monoclonal Antibody (7D10G8E2)

Applications

ELISA

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Target Information

Bone Morphogenic Proteins (BMPs) are members of the TGF-beta superfamily involved in bone and cartilage formation (Hogan 1996, Reddi 1998, Francis-West et al. 1999). Mature BMPs are 30–38 kDa proteins with a TGF-beta-like cysteine knot configuration. Lovostatin increases bone formation by activating the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of bone matrix proteins and influence stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). They also play roles in visceral development, cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs are key regulators of dorsal/ventral patterning and signal through type II and type I receptors to activate the Smad pathway (Massague 1994, Derynck 1997, Attisano 1993).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.