Thermo Fisher Scientific CD26 Monoclonal Antibody (M-A261)
Human CD26(DPP4) 인식하는 Mouse IgG1 단일클론 항체로, IHC(F), Flow Cytometry, ELISA, IP 등 다양한 응용에 사용 가능. Protein G 정제, PBS buffer에 0.09% sodium azide 포함. 형식은 액상이며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
| ELISA | - | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M-A261 |
| Immunogen | Human T-cell leukaemia cells (T-CLL) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955200 |
Product Specific Information
The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. For immunohistochemistry, acetone fixation for frozen sections is recommended.
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV; adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocytes and upregulated during T-cell activation, also found on activated B cells, NK cells, and epithelial tissues.
CD26 participates in:
- T-cell activation
- Cell adhesion with extracellular matrix (fibronectin, collagens)
- HIV infection
It is identical to adenosine deaminase complexing protein-2 and the T-cell activation antigen CD26. CD26 acts as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 activity are linked to malignant transformation and correlate with tumor grade and severity. Changes in CD26 density have been observed on circulating monocytes and CD4+ T cells in rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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