Thermo Fisher Scientific SEPT5 Polyclonal Antibody
Rabbit polyclonal antibody against human SEPT5 protein. Validated for Western blot and IHC (paraffin). Affinity purified and supplied in PBS with 50% glycerol. Suitable for research on cytoskeletal organization and cell division regulation.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–30 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Septin 5 (amino acids 77–323 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903905 |
Target Information
This gene belongs to the septin family of nucleotide-binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are conserved across species such as yeast, Drosophila, and mouse, and are involved in cytoskeletal organization. Disruption of septin function can disturb cytokinesis, leading to multinucleate or polyploid cells.
The SEPT5 gene is located on chromosome 22q11, a region often deleted in DiGeorge and velocardiofacial syndromes. Translocations involving SEPT5 and the MLL gene have been observed in acute myeloid leukemia. Two major transcripts (2.2 kb and 3.5 kb) are known, differing by polyadenylation site usage. An alternatively spliced variant with a different 5′ end has also been identified, though its full-length sequence is not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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