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Thermo Fisher Scientific GPNMB Monoclonal Antibody (HOST5DS), APC, eBioscience

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인간 GPNMB 단백질을 인식하는 HOST5DS 단클론 항체로, APC 형광체가 결합된 제품입니다. Flow Cytometry 분석에 최적화되어 있으며, 고순도 정제된 액상 형태로 제공됩니다. 면역 조절 및 암 연구용으로 적합합니다.

브랜드: Thermo Fisher Scientific
카테고리: Monoclonal Antibodies
판매단위: pk

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마지막 업데이트 2025. 08. 04. 오후 02:19

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Thermo Fisher Scientific 17-9838-42 GPNMB Monoclonal Antibody (HOST5DS), APC, eBioscience 100 tests pk판매 단위 pk ·

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562,100원VAT 포함 618,310원

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Thermo Fisher Scientific · Thermo Fisher Scientific GPNMB Monoclonal Antibody (HOST5DS), APC, eBioscience

Thermo Fisher Scientific GPNMB Monoclonal Antibody (HOST5DS), APC, eBioscience

Applications

Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.125 µg)/test

Product Specifications

항목	내용
Species Reactivity	Human
Host / Isotype	Mouse / IgG1, kappa
Recommended Isotype Control	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™
Class	Monoclonal
Type	Antibody
Clone	HOST5DS
Immunogen	FC-tagged full protein expressed in insect cells
Conjugate	APC
Excitation / Emission Max	651 / 660 nm
Form	Liquid
Concentration	5 µL/Test
Purification	Affinity chromatography
Storage Buffer	PBS, pH 7.2, with 0.2% BSA
Contains	0.09% sodium azide
Storage Conditions	4°C, store in dark, DO NOT FREEZE
Shipping Conditions	Ambient (domestic); Wet ice (international)
RRID	AB_2802235

Additional Formats

PE conjugate available
Custom conjugation request possible

Product Specific Information

This HOST5DS monoclonal antibody recognizes human GPNMB, also known as Osteoactivin, DC-HIL, and HGFIN.
GPNMB is a type-1 transmembrane glycoprotein involved in bone development, tumor progression, neurokinin signaling, and immune regulation. It is expressed on macrophages and dendritic cells and interacts with Syndecan-4 (SD-4) on T cells to inhibit their activation and proliferation.

Surface expression of GPNMB on myeloid cells may indicate tolerogenic properties. Various cancers express GPNMB, aiding in immune evasion. Expression is upregulated by IL-10 and immunosuppressive drugs such as dexamethasone. THP-1 and U937 cell lines constitutively express GPNMB, which may also be secreted.

The HOST5DS antibody is effective on paraformaldehyde-fixed and permeabilized cells and suitable for intracellular staining. Note that enzymatic tissue dissociation may reduce surface GPNMB levels and staining brightness.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and tested on human monocyte-derived macrophages at 5 µL (0.125 µg)/test
A test is defined as the amount of antibody that stains a cell sample in 100 µL final volume. Cell number may range from 10⁵ to 10⁸ cells/test.

Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser

Target Information

GPNMB is a type I transmembrane glycoprotein homologous to pMEL17, a melanocyte-specific protein. It is expressed in lowly metastatic melanoma cell lines but not in highly metastatic ones, suggesting a role in growth delay and reduced metastatic potential. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.