Thermo Fisher Scientific ARK5 Polyclonal Antibody
ARK5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에서 Western blot과 IHC(P) 실험에 적합합니다. 고순도 정제 및 안정한 PBS buffer 포뮬레이션으로 제공되며, 암 전이 관련 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 604–634 from the C-terminal region of human ARK5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2283115 |
Target Information
NUAK1 (ARK5) is a serine/threonine kinase involved in multiple cellular processes. Overexpression of this kinase is associated with tumor invasion and metastasis, particularly in colorectal cancer. It regulates cellular senescence and ploidy by phosphorylating LATS1 at Ser-464, controlling its stability. ARK5 also influences cell adhesion through regulation of the myosin protein phosphatase 1 (PP1) complex by phosphorylating PPP1R12A, which interacts with 14-3-3 proteins to modulate myosin MLC2 dephosphorylation.
Additionally, ARK5 may participate in DNA damage response by phosphorylating p53/TP53 at Ser-15 and Ser-392 and contributing to transcriptional activation of CDKN1A/WAF1. It may promote tumor invasion and metastasis under AKT1 regulation and suppress Fas-induced apoptosis by phosphorylating CASP6. ARK5 also plays a role in UV-induced DNA damage response by phosphorylating CDKN1A in association with STK11, facilitating its degradation for efficient DNA repair.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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