Thermo Fisher Scientific CRY1 Polyclonal Antibody
CRY1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도 Affinity Chromatography로 정제되었습니다. 세포 내 위치는 Cytoplasm 및 Nucleus에 주로 존재합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 496–586 of human CRY1 (NP_0040661) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.92 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805510 |
Product Specific Information
- Positive Samples: Mouse testis, Mouse eye, Rat testis, SW480
- Cellular Location: Cytoplasm, Nucleus
- Immunogen Sequence:
GLGLLASVPS NPNGNGGFMG YSAENIPGCS SSGSCSQGSG ILHYAHGDSQ QTHLLKQGRS SMGTGLSGGK RPSQEEDTQS IGPKVQRQST N
Target Information
Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are key regulators of circadian rhythms, functioning through transcriptional and post-translational feedback loops. These DNA-binding flavoproteins share homology with blue-light receptors and photolyases. In Drosophila, CRY acts as a light-dependent photoreceptor, while mammalian CRY1/CRY2 interact with CLOCK, BMAL1, PER1, PER2, and TIM to regulate circadian gene expression. Proper balance between CRY1 and CRY2 is essential for maintaining rhythmicity; double mutants exhibit arrhythmicity, indicating loss of internal clock function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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