Thermo Fisher Scientific SEPT5 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116, mouse brain
• Predicted reactivity: Mouse (100%), Rat (99%), Xenopus laevis (94%), Chicken (95%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene belongs to the septin gene family of nucleotide-binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved across species and play a role in cytoskeletal organization. Disruption of septin function affects cytokinesis, leading to multinucleate or polyploid cells.
The SEPT5 gene is located on chromosome 22q11, a region associated with DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and SEPT5 has been observed in acute myeloid leukemia.
Two transcripts (2.2 kb major and 3.5 kb minor) are produced due to alternative polyadenylation. An alternatively spliced transcript variant with a different 5′ end has also been identified but not fully characterized.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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