Thermo Fisher Scientific IL6R Monoclonal Antibody (OTI1B5), TrueMAB
인간 IL6R을 인식하는 Mouse IgG2a 단클론 항체로, Western Blot에 적합합니다. HEK293T 세포에서 발현된 full-length 인간 IL6R 단백질을 면역원으로 사용했습니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Full length human recombinant protein of human IL6R produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. IL6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
The IL6 receptor complex consists of this protein and the interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines.
Dysregulated production of IL6 and IL6R is implicated in diseases such as multiple myeloma, autoimmune disorders, and prostate cancer.
Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is located on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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