Thermo Fisher Scientific IL6R Monoclonal Antibody (OTI1B5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. IL6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
The IL6 receptor complex consists of this protein and the interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines.
Dysregulated production of IL6 and IL6R is implicated in diseases such as multiple myeloma, autoimmune disorders, and prostate cancer.
Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is located on chromosome 9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.