Thermo Fisher Scientific Phospho-TEK (Tyr1102) Polyclonal Antibody
인간 및 생쥐 반응성의 Rabbit Polyclonal 항체로, TEK(TIE2) Tyr1102 인산화 부위를 인식합니다. IHC(P) 및 peptide-ELISA에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C 보관하며 연구용으로 적합합니다.
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Thermo Fisher Scientific Phospho-TEK (Tyr1102) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Peptide-ELISA (pep-ELISA) | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human TIE2 around the phosphorylation site of Tyr1102 (K-T-YP-V-N) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554995 |
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
Angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development.
Immunoblotting showed that TIE2 expression increases by thyroid-stimulating hormone and agents that raise intracellular cAMP.
Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent and antiapoptotic, forming a side population adhering to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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