Thermo Fisher Scientific SERTAD1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive control: Molt-4
• Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
Acting at E2F-responsive promoters, SEI-1 interacts with PHD- and bromodomains of proteins such as TIF1 and DP-1, stimulating transcriptional activity.
It forms a multiprotein complex with E2F-1 and DP-1, expressed at varying levels throughout the cell cycle, regulating progression via promoter control during G1 and S phases.
SEI-1 can make the cyclin D-Cdk4 complex resistant to p16 inhibition, and its overexpression has been linked to squamous cell carcinomas of the head and neck.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.