Thermo Fisher Scientific SERTAD1 Polyclonal Antibody
SERTAD1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 검증 완료. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포주 Molt-4 양성 대조로 권장되며, 장기 보관 시 -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 1–44 of Human SERTAD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545936 |
Product Specific Information
- Recommended positive control: Molt-4
- Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
Acting at E2F-responsive promoters, SEI-1 interacts with PHD- and bromodomains of proteins such as TIF1 and DP-1, stimulating transcriptional activity.
It forms a multiprotein complex with E2F-1 and DP-1, expressed at varying levels throughout the cell cycle, regulating progression via promoter control during G1 and S phases.
SEI-1 can make the cyclin D-Cdk4 complex resistant to p16 inhibition, and its overexpression has been linked to squamous cell carcinomas of the head and neck.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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