Thermo Fisher Scientific Phospho-Syk (Tyr317) Polyclonal Antibody
Phospho-Syk (Tyr317) 특이적 Rabbit Polyclonal Antibody로 인체 및 마우스 시료에 반응. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. Dulbecco’s PBS 기반 저장용액, BSA 및 sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- 44233G
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse Syk that contains tyrosine 317 (tyrosine 323 in the human sequence). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533611 |
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) triggering, phosphorylating downstream adaptor proteins and initiating signaling pathways such as calcium mobilization, cytoskeleton remodeling, and gene transcription.
Syk binds to receptor assemblies through its pair of SH2 domains interacting with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk via phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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