Thermo Fisher Scientific SPINK5 Polyclonal Antibody
Human SPINK5 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA552820
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SPINK5. Recombinant protein control fragment (Product #RP-89259) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647862 |
Product Specific Information
Immunogen sequence:
QQEERARAKA KREAAKEICS EFRDQVRNGT LICTREHNPV RGPDGKMHGN KCAMCASVFK LEEEEKKNDK EEKGKVEAEK VKREAVQELC SEYRHYVRNG RLPC
Highest antigen sequence identity to the following orthologs:
- Mouse: 68%
- Rat: 73%
Target Information
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor that protects mucous epithelia against microbial attack and inflammation. LEKTI serves as a marker of epithelial differentiation and is strongly expressed in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia.
Defects in SPINK5, the gene encoding LEKTI, cause Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever, and related conditions.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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