Thermo Fisher Scientific SPINK5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SPINK5. Recombinant protein control fragment (Product #RP-89259). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SPINK5,uniProtId:Q9NQ38-1,ncbiNodeId:9606,antigenRange:478-581,antigenLength:1064,antigenImageFileName:PA5-52820_SPINK5_Q9NQ38-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52820_SPINK5_Q9NQ38-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647862

Product Specific Information

Immunogen sequence: QQEERARAKA KREAAKEICS EFRDQVRNGT LICTREHNPV RGPDGKMHGN KCAMCASVFK LEEEEKKNDK EEKGKVEAEK VKREAVQELC SEYRHYVRNG RLPC

Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 73%.

Target Information

Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.