Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), DyLight 650
HIF1A 단백질을 검출하기 위한 DyLight 650 형광 표지 단일클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 높은 특이성과 안정적인 형광 신호 제공. 연구용으로만 사용.
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Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), DyLight 650
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:5000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:5000 |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESEE122 |
| Immunogen | Human HIF-1 alpha amino acids 329–530 |
| Conjugate | DyLight™ 650 |
| Excitation / Emission Max | 651 / 673 nm |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151853 |
Available Formats
Product Specific Information
Suggested positive control: Cos7 CoCl₂-treated nuclear extract.
Target Information
HIF1-alpha (HIF1A) is a subunit of HIF1, a transcription factor found in mammalian cells under reduced oxygen tension. HIF-1 is a heterodimer composed of alpha and beta subunits, both belonging to the PAS family of transcription factors. It regulates the adaptive response to hypoxia by activating transcription of genes such as erythropoietin, glucose transporters, glycolytic enzymes, and VEGF.
HIF1-alpha influences hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. It interacts with p53 under hypoxic conditions to regulate its own expression via MDM2-mediated ubiquitination. Additionally, HIF1-alpha induction of NOX4 helps maintain ROS levels and supports hypoxia-induced proliferation.
In humans, HIF1A is located on chromosome 14q and its C-terminal region binds to p300, forming complexes that induce hypoxia-responsive genes. Hypoxia plays a key role in diseases such as ischemia, cancer, pulmonary hypertension, congenital heart disease, and COPD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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