Thermo Fisher Scientific CD51 Polyclonal Antibody
Thermo Fisher Scientific의 CD51 폴리클로날 항체는 인간, 마우스, 랫트 반응성을 가지며 WB, IHC, ICC/IF, Flow Cytometry 등에 사용됩니다. Goat IgG 기반 비결합 항체로, 항원 친화 크로마토그래피로 정제되었으며 PBS+trehalose 버퍼에 보존됩니다. 연구용으로만 사용 가능합니다.
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- PA547096
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL | - |
| Flow Cytometry (Flow) | 2.5 µg per million cells | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human Integrin alpha V/CD51 (Phe31–Val992) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609681 |
Product Specific Information
- In Western blots, less than 1% cross-reactivity with recombinant human Integrin alpha 5 and recombinant mouse Integrin E is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, which combine with multiple integrin beta chains to form different integrins.
Among the known associating beta chains (β1, β3, β5, β6, and β8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands. The αVβ3 integrin, also known as the Vitronectin receptor (VNR), is one of the most studied.
In addition to adhesion, many integrins facilitate signal transduction. The ITGB3 protein product is the integrin beta chain β3, which combines with the alpha IIb chain in platelets. Integrins participate in cell adhesion and cell-surface mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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