Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
ARHGEF7 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ARHGEF7 (Accession Q14155), corresponding to amino acid residues N311–Y361 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854530 |
Product Specific Information
This antibody detects endogenous levels of total ARHGEF7.
Target Information
The serine/threonine kinase p21-activated kinase (PAK) acts downstream of the small GTPases Cdc42 and Rac. PAK interacts with Nck, PI3-kinase subunits (p85 and p110), and PIX (PAK-interacting exchange factor) within focal complexes. PIX binding is essential for PAK localization and activation in the Cdc42–Rac signaling pathway, mediated by the SH3 domain of PIX recognizing a conserved proline-rich sequence in PAK. PIX exists as two isoforms, alpha and beta, both highly expressed in heart, muscle, and thymus tissues in humans and rats. The alphaPIX isoform functions primarily as a guanine nucleotide exchange factor (GEF) on Rac, contributing to lamellipodia formation and is regulated by PDGF and EphB2 receptor signaling or PI3-kinase association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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