Thermo Fisher Scientific KMT2D Polyclonal Antibody
KMT2D 단백질을 인식하는 염소 유래 polyclonal 항체로, IHC(P) 등 다양한 응용에 사용 가능. 히스톤 메틸트랜스퍼레이스 KMT2D 연구에 적합하며, 고순도 액상 형태로 제공. -20°C에서 보관, 동결/해동 반복 방지 필요.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 4 µg/mL
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence DSQNLAGEDKDSQ-C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me).
H3K4me represents a specific tag for epigenetic transcriptional activation.
KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription.
It is involved in chromatin organization, chromatin silencing, oocyte growth, oogenesis, and positive regulation of cell proliferation.
Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1), resulting in congenital mental retardation syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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