Thermo Fisher Scientific Human FGF-basic (FGF-2/bFGF) (154 aa), Animal-Free Recombinant Protein, PeproTech

Applications

Western Blot (WB)

• Tested Dilution: -
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Functional Assay

• Assay-dependent
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In vitro Assay (IV)

• Tested Dilution: -
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Miscellaneous PubMed (Misc)

• Tested Dilution: -
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Immunostaining (IS)

• Tested Dilution: -
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Product Specifications

Product Specific Information

Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Qualified for stem cell use.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways.
In humans, the gene is located on the q arm of chromosome 4. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth.
The mRNA for FGF2 contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms.
The CUG-initiated isoforms are nuclear and responsible for intracrine effects, while the AUG-initiated form is cytosolic and responsible for paracrine and autocrine effects.
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.