Thermo Fisher Scientific CD217 (IL-17Ra) Monoclonal Antibody (J10MBS), PE, eBioscience

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: 5 µL (0.25 µg)/test
  • View 3 publications

Product Specifications

Product Specific Information

Description:
The J10MBS monoclonal antibody reacts with human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein (~96 kDa, 866 amino acids) involved in inflammatory responses to IL-17A, IL-17F, and IL-17AF heterodimer. It forms heterodimeric complexes with other receptor family members, including IL-17RC for IL-17A/F signaling and IL-17RB for IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, with elevated expression on granulocytes and monocytes.

Applications Reported:

• Flow cytometric analysis.

Applications Tested:

• Pre-titrated and tested by flow cytometric analysis of human lysed whole blood.
• Recommended use: 5 µL (0.25 µg) per test (in 100 µL final volume).
• Cell number: 10⁵–10⁸ cells/test (to be determined empirically).

Fluorescence Characteristics:

• Excitation: 488–561 nm
• Emission: 578 nm
• Compatible Lasers: Blue, Green, Yellow-Green
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes and induces maturation of CD34⁺ hematopoietic precursors into neutrophils. IL-17RA is a type I membrane glycoprotein binding IL-17A and IL-17F with low affinity. IL-17A and IL-17RA play pathogenic roles in inflammatory and autoimmune diseases such as rheumatoid arthritis. Mutations in IL-17RA cause familial candidiasis type 5 (CANDF5), characterized by altered immune responses and impaired fungal clearance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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