Thermo Fisher Scientific PIM2 Polyclonal Antibody
Human 및 Mouse에서 반응하는 PIM2 단백질에 대한 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제, 1 mg/mL 농도의 액상 시약. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 53–278 of PIM2 (Uniprot ID: Q9P1W9) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152131 |
Product Specific Information
- Recommended positive controls: 293T, mouse testis
- Predicted reactivity: Mouse (91%), Rat (91%), Rhesus Monkey (99%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PIM2 is a proto-oncogene that phosphorylates BAD, partially inhibiting its apoptotic function. PIM proteins (PIM-1, PIM-2, and PIM-3) are oncogene-encoded serine/threonine kinases. PIM-2 is highly homologous to PIM-1 with similar oncogenic functions. It is most abundantly expressed in hematopoietic tissues, spleen, thymus, peripheral blood leukocytes, testis, small intestine, and colon. PIM2 expression is negatively regulated by growth factor depletion, and increased levels have been observed in certain cancers.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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