Thermo Fisher Scientific CD1D Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Chimpanzee

Target Information

CD1d is a heavy chain associated with beta-2 microglobulin on cortical thymocytes. Beta-2 microglobulin–independent expression of CD1d has also been demonstrated on human intestinal epithelial cells.
CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, structurally related to MHC proteins, and forms heterodimers with beta-2-microglobulin.
CD1 proteins mediate the presentation of lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. These family members differ in cellular localization and specificity for particular lipid ligands.
The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.