Thermo Fisher Scientific WDR59 Polyclonal Antibody
WDR59 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 완충액에 보관되며 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human WDR59. Recombinant protein control fragment (Product # RP-104851) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663723 |
Product Specific Information
Immunogen sequence:
GSLTYSDPRER ERDQHDKNKR LLDPANTQQF DDFKKCYGEI LYRWGLREKR AEVLKFVSCP PDPHKGIEFG VYCSHCRSEV RGTQCAICKG FTFQCAIC
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 71%
Target Information
As a component of the GATOR subcomplex GATOR2, WDR59 functions within the amino acid-sensing branch of the TORC1 signaling pathway. It indirectly activates mTORC1 and the TORC1 signaling pathway through inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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